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Rashmika Mandanna and Ayushmann Khurrana Starrer Thamma Releases on OTT_我的网站
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China has granted marketing approval of its first drug for the prevention of acute mountain sickness, filling the long-standing gap in the domestic market where no such medications had been available, Science and Technology Daily reported on Tuesday.
The National Medical Products Administration (NMPA) has approved the marketing of acetazolamide sustained-release capsules, the report said. As the first specialized drug in China indicated for preventing of acute mountain sickness, its approval marks the end of the country's lack of dedicated preventive treatment for altitude illness.
By inhibiting the activity of carbonic anhydrase, acetazolamide promotes the renal excretion of bicarbonate, corrects respiratory alkalosis caused by hypoxia at high altitudes, thereby regulating acid-base balance, optimizing respiratory status, elevating blood oxygen levels, and reducing the risk of onset at the source.
In contrast to health products that only provide auxiliary regulatory effects, this medication has been validated through stringent clinical trials and stands as a specialized drug approved by the NMPA with a clear indication for prevention, said the report.
Led by principal investigator is Luobu Gesang, a deputy dean of the People's Hospital of Xizang Autonomous Region, the clinical trial was designed by his team and has yielded critical evidence to inform prevention strategies for altitude sickness that are specifically adapted to Chinese and Asian populations.
"Previously, although acetazolamide had already been used internationally for the prevention of acute mountain sickness, China had long lacked an NMPA-approved acetazolamide formulation supported by rigorous clinical trials. Furthermore, the existing international formulations were short-acting tablets requiring multiple daily doses, and no drugs with the relevant indication were available on the domestic market for an extended period," said Luobu Gesang.
The sustained-release capsule approved this time not only fills this critical gap but also optimizes the dosage form, providing more reliable and convenient medication protection for the physical health and life safety of people entering high-altitude areas, he added.
Clinical trials showed that, compared with the placebo group, the incidence of acute mountain sickness in the medication group was significantly reduced, with the incidence of moderate-to-severe acute mountain sickness decreasing by 14.6 percent, according to the report.
Related research has been published in the international flagship journal of high-altitude medicine, High Altitude Medicine & Biology.
Global Times
。 Rashmika Mandanna and Ayushmann Khurrana starrer Thamma has officially released on an OTT platform on December 16, 2025. The supernatural horror-comedy movie is produced by Dinesh Vijan under the banner of Maddock Films and Amar Kaushik. It is directed by Aditya Sarpotdar. The movie is written by Niren Bhatt, Arun Fulara and Suresh Mathew. Alongside Ayushmann and Rashmika, the film stars Nawazuddin Siddiqui in the lead with Paresh Rawal and Faisal Malik playing pivotal roles. It also has special appearances from Varun Dhawan, Abhishek Banerjee, Nora Fatehi and Malaika Arora. Opening up about Thamma's success in the theatres and the makers' decision of releasing it on OTT, Ayushmann Khurrana said, "Thamma is unlike any other supernatural or horror movie, perfectly combining supernatural and horror elements with humour, romance, drama, and a heartfelt love story—something you don’t often see. That’s what excited me the most about doing it. I hunt for freshness and newness in cinema and storytelling, and I loved the script when I heard it. After all the love we’ve received, I’m glad that this unique film is now coming to Prime Video, where it can entertain not just audiences in India but viewers around the world who enjoy unconventional narratives."Rashmika Mandanna shared, "Working on a supernatural comedy like Thamma was a first for me, and it was truly an amazing experience. The storyline, my character, the scale—everything about it felt just right, making it an entertaining film not only for audiences but also for me. I am thrilled that the film will now reach even more people around the world when it streams on Prime Video."Nawazuddin Siddiqui further spoke about his character and the reason he chose to be associated with the film. He said, "The character of Yakshasan in Thamma instantly caught my attention because it was unlike anything I had ever done before. Reading about mythological beings like vampires is one thing, but portraying one on screen was an experience I can’t truly put into words. The film has received a wonderful response so far, and I am now looking forward to seeing how people connect with it once it starts streaming on Prime Video." Dinesh Vijan, producer and founder of Maddock Films, shared, "With Thamma, we set out to expand on a world that is larger-than-life, and yet rooted in our folklore in the kind of storytelling Maddock Films believes in by blending different genres such as humoir, romance, and horror that come together in a fresh and distinctive way. Our longstanding collaboration with Prime Video is driven by a shared belief in taking fresh, unconventional Indian stories to new and diverse audiences. The worldwide premiere of Thamma on December 16 marks an important step in that journey, allowing the film to reach a much wider global audience and further expand the Maddock Horror Comedy Universe in every corner."Also Read: Thamma Fame Rachit Singh & Aneet Padda’s Acting Coach Has This to Say About Saiyaara Star’s Success。
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